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Acta Médica Peruana

versión On-line ISSN 1728-5917


CASTANEDA, Oswaldo et al. Evaluation of the efficacy and safety of the orally association of hyaluronic acid, glucosamine sulfate, chondroitin sulfate and methylsulfonylmethane compared with the association of glucosamine sulfate, chondroitin sulfate and methylsulfonylmethane in knee osteoarthritis. Acta méd. peruana [online]. 2014, vol.31, n.3, pp.157-164. ISSN 1728-5917.

Objective. To compare the efficacy and safety of the orally combination of hyaluronic acid (HA), glucosamine sulfate (GS), chondroitin sulfate (CS) and methylsulfonylmethane (MSM) versus GS, CS and MSM for controlling the symptoms of osteoarthritis (OA) knee. Material and Methods. Prospective randomized, double-blind, comparative study, in patients with knee OA were divided into two groups for three months of daily treatment, orally. Group 1 received HA 120 mg + GS 1500 mg + CS 1200 mg + MSM 1000 mg, and group 2, the same association but without HA. Men and women aged 40 years and under 80 years diagnosed with knee OA were included, according to the modified criteria of the American College of Rheumatology (ACR). Four evaluations, initial and at 4, 8 and 12 weeks of treatment were made. Pain was assessed with the WOMAC 3.1 scale and visual analogue scale (VAS) and health status with the SF-36 version 2 questionnaire. In all patient visits provided a form to record the presence of any adverse events. Results. Groups 1 and 2 were similar in age, gender, level of education and sick time, without statistically significant differences. All patients fulfilled the ACR criteria. Group 1 had better scores with statistically significant difference in VAS variable among all groups at week 12 and the SF-36 variable in week 12. Conclusions. It can be concluded that HA-GS-CS-MSM orally association would be more effective and equally safety that GS-CS-MSM association in controlling the symptoms of knee OA.

Palabras clave : osteoarthritis; hyaluronic acid; safety.

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