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Acta Médica Peruana
On-line version ISSN 1728-5917
Abstract
SALAZAR-GRANARA, Alberto Alcibíades et al. Analgesic and neurobehavioral effect of the interaction between Tramadol and Diclofenac in escalated doses in mice. Acta méd. peruana [online]. 2015, vol.32, n.2, pp.91-97. ISSN 1728-5917.
Objective. Determine the effect on pain and nervous system of the interaction between tramadol and diclofenac, in escalating doses. Materials and methods. 60 albino mice, divided into ten groups were used; four groups were for interaction and they received tramadol VO 10 mg/Kg and diclofenac in staggered doses (10, 15, 20 and 25 mg/Kg). Six groups received tramadol 10 mg/Kg; diclofenac 10 mg/Kg; diazepam, 25 mg/ Kg; caffeine, 25 mg/Kg and distilled water, 0.1 mL/10 g; this last group received no medication. The substances were administered one hour before pain induction. Writhing test assessed the effect on pain and Irwin test evaluated the nervous system. The statistical validation of the writhing inhibition percentage, latency percentage, number of writhes and latency was performed using ANOVA one tail, Tukey and Pearson correlation. For Irwin test, Fisher's test was applied. Results. The percentage of writhing inhibition were 55.1%, 89.9%, 74.5% and 94.5% by interaction groups 2, 4, 7 and 10, respectively, versus 31.6% (tramadol), 19.4% (diclofenac) and 4.8% (control). The latency period was 609.7; 891.2; 860.5 and 1100 seconds by interaction groups 2, 4, 7 and 10, respectively, versus 479.7 (tramadol), 281.8 (diclofenac) and 475.7 seconds (control). ANOVA showed significant differences (p < 0.05; CI 95%) relative to the percent inhibition of contortions and the latency period. Irwin test showed piloerection, sedation, increased respiration, motor incoordination and Straub tail. Conclusions. Synergistic analgesic effect of co-administration of fixed dose tramadol and diclofenac dose escalation was found.
Keywords : analgesics; tramadol; diclofenac; drug synergism.