Abstract

ANDUAGA-BERAMENDI, Alexander et al. Risk factors for drug-sensitive tuberculosis therapy failure in a primary care health center in Lima, Peru. Acta méd. peruana [online]. 2016, vol.33, n.1, pp.21-28. ISSN 1728-5917.

Objective: To identify associated factors with failure of antituberculous therapy in a primary health center in Chorrillos, Lima, Peru. Material and methods: Retrospective case control study with a 1:3 case-control ratio. A case was defined as a patient who discontinued the treatment for a period of 30 consecutive days or more, and a control as a patient successfully completing antituberculous therapy. The score for risk of failure measured in the health center (≥22) and demographic variables wereassessed. Odds ratios (OR) and95%confidenceintervals (CI) werecalculatedusing logistic regression. Results: Thirty-four cases and 102 controls were included. In the multivariate analysis, factors associated to a greater likelihood for a failure in antituberculous therapy were to have less than six years of education (OR: 22,2; 95% IC: 1,9-256,1) and to obtain a score greater or equal than 22 points in the test for risk of failure (OR= 21,4; 95% IC: 6,3-72,4). Conclusions: Failure of antituberculous therapy was associated with having less than six years of education and a score greater than or equal to 22 points in the test for risk of failure.

Keywords : Tuberculosis; Risk factors; Medication adherence; Therapy.

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