Abstract

MONTALVO, Raúl et al. Mortality in patients with HIV / AIDS on antiretroviral treatment in Huancayo, Peru 2008-2015. Acta méd. peruana [online]. 2016, vol.33, n.2, pp.119-125. ISSN 1728-5917.

Objective: To evaluate mortality in patients with HIV / AIDS receiving antiretroviral therapy (ART) in a public hospital in Peru. Materials and Methods: An observational retrospective cohort study of patients diagnosed with HIV / AIDS receiving antiretroviral treatment was performed. Results: Of 428 patients studied, the mean age was 37 years and the average CD4 count at ART initiation in the group of death was 87.2 cells / uL vs. 153.2 cells / uL in the group of living , they died 66 patients (15.4%) after starting ART. Most (48.5%) of these patients had CD4 counts less than 200 cells / uL, 59.1% developed opportunistic infection and 16.7% changed their antiretroviral regimen sometime in the ART. Mortality during the first 3 months of ART was 32.6%; Multivariate analysis found association have more than 100 CD4 cells / mL (HR: 0.57; 95% CI: 0.29 to 1.11), the presence of opportunistic infection (HR: 1.1; 95% CI 1.06 to 1.16) and have a high viral load (HR 1.17; 95% CI: 1.07 to 1.48). The probability of survival of patients with less than 100 CD4 cells / mL at 8 years in ART is 68%. Conclusions: The highest number of deaths of patients with HIV / AIDS occurs during the first three months of ART and is associated with late diagnosis (high viral load, low CD4 and presence of opportunistic infections). We suggest the implementation of supervised therapy in patients with less than 100 CD4 cells / mL during the first months of ART, to identify early opportunistic infections.

Keywords : Mortality; HIV; Acquired immunodeficiency syndrome; Antiretroviral therapy.

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