Abstract

SALAZAR-CARRILLO, Yuvidtza et al. Criptococosis cutánea localizada en paciente trasplantada renal: una entidad infrecuenteLocalized cutaneous cryptococcosis in a patient who underwent a kidney transplantation: an unusual condition. Acta méd. Peru [online]. 2018, vol.35, n.2, pp.133-137. ISSN 1728-5917.

Cutaneous cryptococcosis is an uncommon condition in patients undergoing solid-organ transplantation (SOT). The localized cutaneous form has been described in immunosuppressed patients, and it may likely be secondary to a reactivation of a dormant infection in the lymph nodes or in the lungs; also, systemic involvement should be ruled out. We present the case of a 40-year old woman who underwent a renal transplantation one year ago. She received tacrolimus and prednisone for rejection control, and after one week she developed a lesion in the internal aspect of her left thigh, which suggested a bacterial skin and soft-tissues infection. Wide spectrum antimicrobials were started, but the lesion progressed to a necrotic ulcer which had to undergo surgical cleansing. The skin biopsy revealed chronic non-caseating nodular granulomatous dermatitis, with the presence of multiple Cryptococcus yeasts. Cryptococcus neoformans was isolated in the cultured material and antifungal therapy was started. A satisfactory response was achieved. It is necessary to establish screening strategies aiming to prevent cryptococcal infections in patients undergoing SOT

Keywords : Cryptococcosis; Kidney transplantation; Cryptococcus neoformans.

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