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Acta Médica Peruana

versión On-line ISSN 1728-5917


PLASENCIA-DUENAS, Esteban A.; DIAZ-VELEZ, Cristian  y  DUENAS-ROQUE, Milagros M.. Factors associated to the occurrence of cleft lip and palate in newborns in a tertiary care Peruvian hospital. A case-control study. Acta méd. Peru [online]. 2020, vol.37, n.3, pp.304-311. ISSN 1728-5917.


to identify factors associated to the occurrence of cleft lip and/or palate in newborns in Edgardo Rebagliati-Martins National Hospital in Lima, Peru, during the time period from November 2012 until December 2016.

Materials and methods:

this is an analytical observational paired case-control study, with data from the Collaborative Latin-American Study of Congenital Malformations. Sixty-one cases and sixty-one controls were analyzed. The dependent variable was the presence of cleft lip and/or palate. Clinical, epidemiological, obstetric, and prenatal variables were also analyzed.


: cleft lip/palate with complete extension predominantly in males was the most frequent form, and it was present in 36 neonates (59%), 44 of all children in the sample (75.9%) had normal karyotype, and 40 did not have a prenatal diagnosis (65.6%). Associated malformations most frequently observed were 27 facial cases (44.2%), followed by cardiac malformations (29.6%). A statistical model using multivariate analysis was built on, and this comprised three variables: chronic disease during pregnancy (odds ratio (OR): 3.8; 95% confidence interval (CI): 1.11-13.8), maternal age more than 35 years (OR: 6.85; 95% CI: 2.69-17.43), and family history (OR: 14.5; 95% CI: 1.68-125.56).


: chronic diseases during pregnancy, advanced maternal age, and family history were factors that increased the frequency of cleft lip and/or palate.

Palabras clave : Cleft palate; Congenital malformations; Risk factors.

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