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Acta Médica Peruana

On-line version ISSN 1728-5917


FLORES GAVINO, Aldo; ESPINOZA ANCHAYGUA, Ricardo; HERRERA-ANAZCO, Percy  and  RODRIGUEZ-MORALES, Alfonso J.. Effect of SARS-COV-2 on kidney tissue: a narrative review. Acta méd. Peru [online]. 2021, vol.38, n.1, pp.53-57.  Epub May 23, 2021. ISSN 1728-5917.

We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin-Angiotensin-Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.

Keywords : Histopathology; Pathophysiology; SARS-CoV-2; COVID-19; Acute Kidney Injury; Kidney.

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