Abstract

VARGAS-PONCE, Kenneth G. et al. Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017- 2018. Acta méd. Peru [online]. 2021, vol.38, n.2, pp.151-153. ISSN 1728-5917.  http://dx.doi.org/10.35663/amp.2021.382.1892.

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

Keywords : Mycobacterium tuberculosis;Tuberculosis, Multidrug-Resistant; Mutation; Isoniazid; Peru.

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