SciELO - Scientific Electronic Library Online

vol.38 issue3National Medicine Exam: an Analysis of the last decade of theoretical exams in peruvian last year medical students author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Acta Médica Peruana

On-line version ISSN 1728-5917


FERNANDEZ MERJILDO, Diana; LEVANO DIAZ, Lady  and  ZEGARRA PIEROLA, Jaime. Mortality with hydroxichloroquine and azythromycin use in COVID-19 patients undergoing mechanical ventilation in an intensive care unit in Lima. Acta méd. Peru [online]. 2021, vol.38, n.3, pp.163-168. ISSN 1728-5917.


: To estimate mortality rates associated with hydroxichloroquine and azithromycin use in Covid-19 patients undergoing mechanical ventilation in an intensive care unit in Lima.

Material and methods

: This is a retrospective analytical cohort. One hundred and five patients with Covid-19 undergoing invasive mechanical ventilation who were admitted with a diagnosis of acute respiratory insufficiency to the intensive care unit of Cayetano Heredia Hospital in Lima during 2020.


: The overall mortality rate was 38%. Most patients (79%) were male, their mean age was 50 ± 13 years, two thirds (65%) did not have comorbidities; APACHE II and SOFA scores were 12 ± 6 points and 5 ± 3 points, respectively. Thirty percent of all patients received hydroxichloroquine, 32% received azithromycin, and 32% received both drugs. Mortality was significantly higher in those patients who received hydroxichloroquine (p= 0.001), azithromycin (p= 0.03), and the combination of hydroxichloroquine and azithromycin (p= 0.001). However, when a Cox regression analysis was performed, it was evidenced that deceased patients were more likely to have been exposed to hydroxichloroquine (p= 0.001) (HR: 21, CI: 3.4-131.3), but this was not the case with azithromycin (p= 0.22) (HR: 0.43, CI: 0.11-1.6).


: Mortality in Covid-19 patients undergoing invasive mechanical ventilation was higher in those who received hydroxichloroquine.

Keywords : Mortality; Covid-19; Mechanical ventilation; Hydroxichloroquine; Azithromycin.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )