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Revista de la Sociedad Química del Perú
versão impressa ISSN 1810-634X
Resumo
SUN-KOU, María del Rosario; VEGA CARRASCO, Edgar R. e PICASSO ESCOBAR, Gino I.. Catalytic oxidation of albendazole using molybdenum supported on carbon nanotubes as catalyst. Rev. Soc. Quím. Perú [online]. 2013, vol.79, n.4, pp.291-303. ISSN 1810-634X.
The catalytic oxidation reaction of the thioether group (-S-) in the structure to the drug albendazole (C12H15N3O2S) was studied in order to obtain a pharmacologically active molecule known as albendazole sulfoxide. With this purpose, three heterogeneous catalysts were prepared using molybdenum (Mo) as active phase and carbon nanotubes as a multiple-layer catalyst support. The incorporation of the active phase was performed by wet impregnation, with subsequent calcination for 4 hours at 400°C. For the catalytic oxidation reaction was employed hydrogen peroxide-urea (H2NCONH2·H2O2) as oxidizing agent and methanol (CH3OH) as reaction medium. The textural and morphology characterization of carbon nanoparticles and catalysts was carried out by adsorption-desorption of N2 (BET) and scanning electron microscopy (SEM). The identification and quantification of the reaction products were followed by Fourier transform infrared spectroscopy (FTIR) and high performance liquid chromatography (HPLC), respectively. With the yield, selectivity and conversion higher than 90% after 60 minutes of reaction, albendazole sulphoxide was obtained as major product of oxidation reaction.
Palavras-chave : catalytic oxidation; albendazole; albendazole sulphoxide.