Abstract

REYES-GARCIA, Luis J  and  CID, Pia. Synthesis of possible nicotinic agonists with potential insecticide activity. Rev. Soc. Quím. Perú [online]. 2016, vol.82, n.2, pp.175-182. ISSN 1810-634X.

Ethyl N-benzylpyridine-3-carboximidoate⁷ was prepared by reacting N-benzylnicotinamide and ethyl chloroformate, the other ethyl imidatehydrochloride, ethyl N-(2-phenylethyl) pyridine-3-carboximidoate⁸, was prepared with the same method. Compound6 was obtained by synthesis of N-benzyl-N-(2-cyanoethyl) nicotinamide⁴, the latter was used as a starting material to obtain N-(3-aminopropyl)-N-benzylnicotinamide⁵ by reduction with Ni-Raney in good yield. Cyclization reaction was obtained by p-toluenesulfonic acid of compound⁵. Finally, compound (5,6-dihydro-2-(pyridin-3-yl)pyrimidin-1(4H)-yl)(2,4-dimethoxyphenyl) methanone⁹ was prepared by direct benzoylation of 1,4,5,6-tetrahydro-2-(pyridin-3-yl) pyrimidine.

Keywords : Heterocycles synthesis; insecticidal activity; tetrahydropyrimidines.

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