Abstract

LUJAN DE PINEDO, María E et al. Dressing based on Vaccinium corymbosum L. and chitosan with high skin regenerative capacity. Scientia Agropecuaria [online]. 2018, vol.9, n.2, pp.223-229. ISSN 2077-9917.  http://dx.doi.org/10.17268/sci.agropecu.2018.02.07.

The study was aimed at developing a dressing based on Vaccinium corymbosum L. and chitosan with high skin regenerative capacity. Started with the obtaining of the concentrate from the fruit of Vaccinium corymbosum L.; then, a 1% w/v chitosan biofilm was prepared, to which the Vaccinium corymbosum 10% w/v concentrate was incorporated, to obtain the final formulation. The experimental study was based on the random distribution of 24 male Lewis albino strain rats in three contrast groups: control, chitosan dressing, and 10% plus chitosan Vaccinium corymbosum concentrate dressing. The results were evaluated based on the evolution of healing in the injured area from 0 to 21 days (macroscopic level), and, in the histological study of scarring (microscopic level). It is concluded that the development of a dressing of Vaccinium corymbosum L. 10% and chitosan with pharmaceutical quality presented significantly better regenerative capacity by promoting the acceleration of wound healing by reducing the injured area from 7 days of treatment, and increased the promotion of the processes of epithelialization, neovascularization, and proliferation of fibroblasts and collagen.

Keywords : Vaccinium corymbosum L; dressing; chitosan; regeneration; skin.

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