Abstract

ZATTA CONDOR, Julio; VIDAL, Judith  and  RETAMOSO, Rosario. Lineage switch from acute lympheal leukemia (ALL) to acute myeloid leukemia (AML): report of a case. Rev. Cuerpo Med. HNAAA [online]. 2020, vol.13, n.2, pp.183-188.  Epub June 30, 2020. ISSN 2225-5109.  http://dx.doi.org/10.35434/rcmhnaaa.2020.132.671.

Introduction: Acute Lymphatic Leukemia (ALL) represents the most frequent pediatric malignant disease, representing at least 25% of childhood cancer cases. Lineage switch from Acute Lymphatic Leukemia to Acute Myeloid Leukemia (AML) represents approximately 6 to 9% of recurrent cases, and is observed more frequently in children. Case report: a 9-year-old male patient with an Initial Diagnosis of Very High Risk ALL-B, relapses with AML after 1 year 9 months of receiving treatment with chemotherapy and prophylactic radiotherapy. Conclusion: There are different mechanisms that could explain the Lineage switch between acute lymphocytic leukemia to acute myeloid leukemia; in our patient we could talk about possible factors that influenced the Lineage switch: bipolar progenitors, clonal selection, chemotherapy.

Keywords : Lineage Switch; acute leukemia; hospital.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )