SciELO - Scientific Electronic Library Online

vol.13 número4Factores asociados a mortalidad en pacientes Covid- 19 en un Hospital del norte de PerúCaracterísticas de pacientes con alta clínica post SARS-Cov-2 hospitalizados en EsSalud. Región Lambayeque índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo

versión impresa ISSN 2225-5109versión On-line ISSN 2227-4731


MEREGILDO-RODRIGUEZ, Edinson Dante; GUZMAN-AGUILAR, Wilson Marcial; VASQUEZ-TIRADO, Gustavo Adolfo  y  PENA-QUISPE, Camilo. Effect of Parenteral Corticosteroids in Mortality from Severe Covid-19. Rev. Cuerpo Med. HNAAA [online]. 2020, vol.13, n.4, pp.386-394. ISSN 2225-5109.


. Infections caused by SARS-CoV-2 may produce a severe inflammatory response, sepsis, respiratory failure, organ dysfunction, and death. From a pathophysiological point of view, it is plausible that glucocorticoids could be a reasonable therapeutic option for Covid-19. However, the evidence supporting the benefit of corticosteroids on mortality and other clinical outcomes is not conclusive.


: determinate if there exist evidence supporting corticosteroids therapy in patients with severe Covid- 19 and Acute Respiratory Distress Syndrome (ARDS).

Material and method

: This study was performed in concordance with PRISMA guidelines. According to the PICO strategy, Population were patients with severe Covid-19 and/or ARDS; Intervention, parenteral corticosteroid administration; Comparator, patients with severe Covid-19 and/or ARDS with standard treatment (without corticosteroids); and Outcome, mortality and other clinical outcomes. Search strategy was performed in the data bases PubMed, Medline, Cochrane, Embase, and LILACS, using terms related with the PICO question; from January 1 to august 31 (2020). A total of 287 articles were initially retrieved. Of these, we finally selected only 9 article which fulfilled with PICO and selection criteria.


: According to our study, parenteral corticosteroids reduce mortality in patients with Severe Covid-19 and/or ARDS [OR 0.83 (IC 95% 0.63-1.08)].


: the systematic review shows that parenteral corticosteroids could reduce the mortality of patients with severe Covid-19 and ARDS.

Palabras clave : SARS Virus; COVID-19; glucocorticoids; treatment outcome; clinical outcome; mortality.

        · resumen en Español     · texto en Español     · Español ( pdf )