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Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo

Print version ISSN 2225-5109On-line version ISSN 2227-4731


VIRUEZ SOTO, Antonio et al. Lactate clearance and mortality in high altitude residents with severe trauma. Rev. Cuerpo Med. HNAAA [online]. 2021, vol.14, n.3, pp.291-296.  Epub Nov 26, 2021. ISSN 2225-5109.


Several studies report that lactate clearance is associated with mortality in critically ill patients.


To describe the relationship between lactate clearance and lactate normalization with mortality in high-altitude resident patients with severe trauma. To know the mortality of patients with severe trauma at altitude. Know the injury distribution of severe trauma at altitude.


Epidemiological, observational, analytical, cohort, retrospective study, carried out in an intensive care unit located at 4,150 "masl" in patients admitted for severe trauma. The inclusion criteria were: a) Diagnosis of severe trauma. b) Injury severity score greater than 16. c) Presence of the result of the lactate analysis at admission and at 6 hours in the ICU and d) Resident of the altitude since the age of 12. Patients with incomplete and unreadable medical records were excluded.


160 patients were included, mortality of 15%, 65% of the injuries were due to severe brain trauma. In the group of survivors (136), lactate clearance was 52.27% and in the group of deceased it was 21.38%. In relation to normalization (lactate <2 mmol / L), the group of survivors had 47% compared to 1% of the deceased.


Lactate clearance and lactate normalization at 6 hours are protective factors to decrease mortality from severe trauma. Mortality from severe trauma is 15%. Severe head trauma was the most frequent injury.

Keywords : Altitude; Lactic Acid; Severe Trauma; Mortality.

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