SciELO - Scientific Electronic Library Online

vol.14 issue3Maternal characteristic and perinatal outcomes among peruvian women infected with COVID-19. An observational and cross-sectional studyStroke in patients with Covid-19: experiencie in a national referral hospital in Peru author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo

Print version ISSN 2225-5109On-line version ISSN 2227-4731


PICHARDO-RODRIGUEZ, Rafael et al. Morphological characteristics of bone marrows in patients with SARS-COV-2 infection from Hospital 2 de Mayo, Peru. Rev. Cuerpo Med. HNAAA [online]. 2021, vol.14, n.3, pp.352-356.  Epub Nov 26, 2021. ISSN 2225-5109.


It has been described that, at the medullary level, SARS-COV2 can compromise hematopoiesis, manifesting with cytopenias and there are only studies carried out in autopsies.


to describe the morphological characteristics of the bone marrow of patients hospitalized for COVID-19 pneumonia at the Hospital Nacional “Dos de Mayo”.

Materials and methods:

Retrospective cross-sectional observational study carried out in patients over 18 years of age with a confirmed diagnosis of COVID-19 by rapid or molecular testing, and those with incomplete, illegible or missing medical history and / or bacterial or fungal pneumonia were excluded. The findings of the bone marrow readings were confirmed by a trained hematologist, collecting data such as: hemosiderin, cellularity, myelo / erythroid ratio, myeloid series, megakaryocytic and plasma cells. Descriptive statistics based on frequencies and percentages were used for qualitative variables and mean and standard deviation for quantitative variables.


A total of 30 patients were included. The most frequent marrow findings were: macrophages with cytophagocytosis in 87% (n = 26), hyperplasia with arrest in the maturation of myeloid progenitors in 70% (n = 21). 87% (n = 26) of the samples presented eosinophilia. No or little evidence of platelet formation was observed in 57% (n = 17) of the samples. In 40% (n= 12) 6% of plasma cells were found.


Patients with SARS-COV2 infection present medullary alterations, among which are: cytophagocytosis with hyperplasia and maturation arrest in the myeloid series, little or no platelet production in megakaryocytes and eosinophilia.

Keywords : COVID-19; Bone Marrow; Hematopoiesis; Cross-Sectional Studies.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )