Abstract

MALCA T., Magaly; LOPEZ B., Aldo; SANTOS O., Carlos  and  ALVAREZ L., Manuel. Survival prognostic factors in patients with uterine carcinosarcoma. Rev Per Ginecol obstet. [online]. 2013, vol.59, n.2, pp.119-124. ISSN 2304-5132.

Objectives: To determine survival prognostic factors in patients with uterine carcinosarcoma. Design: Retrospective cohort study. Setting: Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru. Participants: Patients with uterine carcinosarcoma. Interventions: A review of medical histories and pathology reports in patients with uterine carcinosarcoma treated from 2005 through 2011 was performed. Statistical analysis used SPSS 19.0 for Windows, with frequencies and summary measures. Survival was estimated using Kaplan-Meier method. Significance was 95%, p< 0.05. Multivariate analysis for prognostic variables was done with Cox proportional hazards model. Main outcome measures: Survival prognostic factors. Results: In 37 patients with uterine carcinosarcoma mean age was 63 years, most of them (67%) presented advanced stages. Non-standardized initial surgery was performed in 33 patients (89%). Only seven patients had pelvic lymphadenectomy (19%) that did not influence overall survival. Omentectomy was done in 15 patients (40%), and eight had metastases to omentum influencing overall survival. Conclusions: Surgical and adjuvant treatments were developed in a non-standardized way. Only factors influencing survival were stage at diagnosis and omentum metastasis. Adjuvant therapy did not improve survival. Omentectomy should be considered in staging.

Keywords : Uterine carcinosarcoma; prognostic factors; survival; FIGO staging.

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