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Revista Peruana de Ginecología y Obstetricia

On-line version ISSN 2304-5132


VENTURA LAVERIANO, Walter Ricardo. Non-invasive prenatal diagnosis based on cell-free fetal DNA: update. Rev. peru. ginecol. obstet. [online]. 2014, vol.60, n.3, pp.233-238. ISSN 2304-5132.

The discovery of cell free fetal DNA (cff-DNA) in maternal circulation has profoundly changed the clinical practice of Obstetrics and knocked down an old paradigm in prenatal diagnosis. Over the past five years screening for chromosomal abnormalities has moved from one with a high false positive rate into another more effective and at lower false positive rate. Undoubtedly, this test is the best effective screening tool in Obstetrics.

Keywords : Cell-free fetal DNA; prenatal diagnosis; aneuploidy; trisomy 21.

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