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Revista Peruana de Ginecología y Obstetricia

On-line version ISSN 2304-5132


LACUNZA PAREDES, Rommel Omar  and  PACHECO-ROMERO, José. Early-and late-onset preeclampsia: an old disease, new ideas. Rev. peru. ginecol. obstet. [online]. 2014, vol.60, n.4, pp.351-362. ISSN 2304-5132.

Significant differences between preeclampsia manifestations before (early-onset) and after 34 weeks (late-onset) raise the possibility that these are two different diseases. This hypothesis is strengthened based on genetic, epidemiological and placental differences. However, recent studies show the possibility of temporal continuity between both clinical phenotypes. In this context antiangiogenic phenomena and their relation with the fetus may be crucial in clarifying this unanswered question.

Keywords : Early-onset preeclampsia; late-onset preeclampsia; antiangiogenic imbalance.

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