Abstract

WAGNER GRAU, Patrick. Pathophysiology of hypertension: New concepts. Rev. peru. ginecol. obstet. [online]. 2018, vol.64, n.2, pp.175-184. ISSN 2304-5132.  http://dx.doi.org/https://doi.org/10.31403/rpgo.v64i2075.

The pathophysiology of hypertension is complex because it involves multiple factors which mostly have a genetic basis. It has been shown that the renin-angiotensinaldosterone system (RAAS) is the most important factor, since it determines the action of other humoral and/or neural factors such as production of endothelin, inhibition of nitric oxide or prostacyclin, action of catecholamines, vasopressin, ouabain-sensitive factor, thromboxane A2 (TxA2) and various vasopressor endogenous agents. In this article, we present a thorough review of what we know today about the RAAS. We also include some new research on this system.

Keywords : Hypertension; Renin; Angiotensin; New angiotensins; Vascular protection.

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