Abstract

APELT-ALCALAY, Daniela  and  REYNA-VILLASMIL, Eduardo. Pure Leydig cell tumor of the ovary in a premenopausal womanPure Leydig cell tumor of the ovary in a premenopausal woman. Rev. peru. ginecol. obstet. [online]. 2020, vol.66, n.2, 00014. ISSN 2304-5132.  http://dx.doi.org/10.31403/rpgo.v66i2257.

Leydig cell tumors of the ovary are a rare type of sex cord-stromal tumors, corresponding to less than 0.1% of all ovarian neoplasms. With a low incidence and frequent false-negative imaging results, these tumors represent a diagnostic challenge. Although more common in menopause, cases have also been described in premenopausal women. The most common clinical feature is rapidly progressive virilization; over 75% of patients show signs of virilization due to testosterone overproduction. Serum testosterone concentration is the most useful marker for diagnosing androgen-secreting tumors of the ovary. Leydig cell tumors should always be considered in women of reproductive age with virilization symptoms. We present the case of a pure Leydig cell tumor of the ovary in a premenopausal woman.

Keywords : Leydig cell tumor; Ovarian neoplasms; Virilization.

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