Abstract

REYNA-VILLASMIL, Eduardo; TORRES-CEPEDA, Duly  and  RONDON-TAPIA, Martha. Miller-Fisher syndrome during pregnancy. Rev. peru. ginecol. obstet. [online]. 2022, vol.68, n.3, 00013.  Epub Sep 22, 2022. ISSN 2304-5132.  http://dx.doi.org/10.31403/rpgo.v68i2437.

Miller-Fisher syndrome is a rare, acute, autoimmune, demyelinating disorder which is considered a variant of Guillain-Barré syndrome. The pathologic mechanism is unclear, but acute demyelinating polyneuropathies may be triggered by bacterial or viral infections, major surgical interventions, or vaccination. Pregnancy may be a trigger of the immune response causing the onset of the syndrome. Miller-Fisher syndrome is characterized by acute onset, with predominant involvement of the facial and cranial nerves resulting in ophthalmoparesis, ataxia, and areflexia/hyporeflexia. Diagnosis is based on clinical suspicion together with the determination of specific ganglioside antibodies and other laboratory and imaging tests. Treatment consists of intravenous immunoglobulin and plasmapheresis, together with supportive measures. There are few reports of the syndrome occurring in pregnant women. A case of Miller-Fisher syndrome during pregnancy is presented.

Keywords : Miller-Fisher syndrome; Guillain-Barre syndrome; Ophthalmoparesis; Ataxia; Pregnancy.

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