Abstract

LA ROTTA-NUNEZ, Elisabeth  and  REYNA-VILLASMIL, Eduardo. Pemphigoid gestationis. Case report. Rev. peru. ginecol. obstet. [online]. 2023, vol.69, n.1, 00013.  Epub Mar 27, 2023. ISSN 2304-5132.  http://dx.doi.org/10.31403/rpgo.v69i2488.

Pemphigoid gestationis, formerly known as herpes gestationis, is a rare, blistering, autoimmune, pregnancy-specific dermatosis. Although the etiology is not fully understood, most patients develop antibodies against 180 kDa transmembrane hemidesmosomal protein. The defining symptoms of the disease are intense itching and urticarial lesions that evolve into painful blisters. Lesions begin in the periumbilical region in 90% of cases and spread rapidly to other areas of the body, except for the head and mucous membranes. It is most frequent in the second or third trimester. In skin biopsy specimens, direct immunofluorescence staining validates the diagnosis. Topical corticosteroids can be used to treat mild symptoms, while oral corticosteroids and antihistamines should be used to treat severe cases. A case of pemphigoid gestationis is presented.

Keywords : Pemphigoid gestationis; Dermatosis; Pregnancy; Pemphigus.

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