Abstract

PACHECO-ROMERO, José. The coronavirus conundrum - BA.2.86 variant of SARS-CoV-2 - What’s new about long COVID - Vaccines - Nobel Prizes. Rev. peru. ginecol. obstet. [online]. 2023, vol.69, n.3, 00008.  Epub Oct 16, 2023. ISSN 2304-5132.  http://dx.doi.org/10.31403/rpgo.v69i2549.

The coronavirus has continued to move around the world with new variants, some of which are of concern. Hospitalizations increased in some places with the BA.2.86 variant, especially in obese or morbid elderly people, but have decreased, as have deaths. Women who gestated by assisted reproductive techniques had similar morbidity as those who gestated spontaneously, but with more adverse maternal-perinatal outcomes in those older, with multiple pregnancies, nulliparity, body mass index >30. Children born at the beginning of the pandemic showed a different microbiome composition than those born before the pandemic, which could affect their health later in life. Among people with long COVID, a quarter of them suffer organ and system sequelae, with limitation and lost years of activity, as well as the possibility of premature death. Long COVID occurs more in women between 35-49 years of age and in those with lower income. They could develop type 2 diabetes. There would be direct interactions between SARS-CoV-2 and mitochondrial proteins essential in energy production. Viral RNA has been detected in coronary atherosclerotic lesions and the spike has been found in skull bones, meninges and brain. Coronavirus vaccines protect pregnant women and their newborns through placental transfer and lactation. In the population, protective immunity from infection and vaccines declines over time and new vaccination will be required at an as yet undetermined regularity.

Keywords : Coronavirus infections; SARS-CoV-2; COVID-19; SARS-CoV-2 vaccines; Pregnant woman; Fetus; Newborn.

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