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Revista de la Facultad de Medicina Humana

Print version ISSN 1814-5469On-line version ISSN 2308-0531


AMADO-CORNEJO, Nathalie D. et al. Anti-inflammatory activity of the ethnolic extract of the leaves of manihot esculenta crantz (yuca) in an experimental model of acute inflammation. Rev. Fac. Med. Hum. [online]. 2020, vol.20, n.1, pp.94-98. ISSN 1814-5469.


Manihot esculenta Crantz(yucca) leaves have been used around the world and over time in order to decrease the anti-inflammatory response.


To evaluate the anti-inflammatory activity of the ethanolic extract of theManihot esculenta Crantzleaf in rats.


An experimental study was conducted. The study population included 60 albino rats sp. Rattus novergicus, distributed in 4 groups of 15 rats each. A homogeneous solution of ethanolic extract of Manihot esculenta Crantz leaves was used for intraperitoneal administration. Carrageenan was used as an inflammatory inducer that was administered intradermally; for the measurement of plantar edema, the Digital Water Plethysmometer (LE7500) was used. Tween 80 / water solution (1:10) was administered to the negative control group at a dose of 1mL./100g., To the betamethasone positive control group 4mg / Kg and to treatment groups 1 and 2Manihot esculenta Crantz, 2 mg / kg and 4 mg / kg, respectively. The 1-tail ANOVA test and the Tukey post hoc test were used for comparisons between the groups.


In 37.67% of treatment group 2 a reduction in edema was observed 3 hours after administeringManihot esculenta Crantz(p <0.05). In both administration groups ofManihot esculenta Crantzthere was a nonsignificant trend to reduce plantar edema with values close to significance.


TheManihot esculenta Crantzethanolic extract at a 4 mg / kg dose probably have anti-inflammatory activity in this animal model of acute inflamation.

Keywords : esculenta Crantz; Inflammation; Edema (source: MeSH NLM)..

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