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Revista de la Facultad de Medicina Humana

Print version ISSN 1814-5469On-line version ISSN 2308-0531


MENDEZ-AGUILAR, Paul  and  VERA-PONCE, Victor Juan. Prognostic factors and survival study in high-grade glioma in a Hospital in Lima, Peru. Rev. Fac. Med. Hum. [online]. 2020, vol.20, n.3, pp.452-463. ISSN 1814-5469.


Gliomas are primary tumors of the central nervous system. They are classified from grade I-IV, with high grade III and IV being the most frequent and with poor prognosis.


To determine the prognostic factors of survival in patients with high-grade gliomas in a hospital in Lima, Peru.


The medical records with high-grade glioma from 2010-2014 were retrospectively reviewed, ten variables were analyzed with Kaplan-Meier and Log Rank survival graphs and the Cox regression model.


Out of a total of 278 patients with high-grade gliomas, 136 were men and 142 women. The analysis of Progression-Free Survival (SLP) had a range of 5.6-80.3 (median 22.7) and the analysis of overall survival (PS) had a range of 4-83.2 (median 26, 2 months. The overall survival for the IV grade tumor was 15.7 months (95% CI 14.2-17.1); the III degree was 38.4 months (95% CI 35.8-40.9). The grade (PS: HR 15; SLP: HR 25.1); surgical treatment (PS: HR 0.6; SLP: HR 0.49), age (PS: HR 1.47; SLP: HR 1.7), adjuvant treatment (PS: HR 0.6; SLP: HR 0 , 58) and karnofsky (PS: HR 0.7) were correlated; while the Karnofsky for SLP does not (P = 0.146).


Age, functional status, surgical treatment, adjuvant treatment, and tumor grade are prognostic factors for PS. In contrast, for SLP the prognostic factors were age, surgical treatment, adjuvant treatment, and tumor grade.

Keywords : progression-free survival; Karnofsky Performance Status; glioma (source MeSH NLM).

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