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Revista de la Facultad de Medicina Humana

versión impresa ISSN 1814-5469versión On-line ISSN 2308-0531


QUINONES-LAVERIANO, Dante M.; SOTO, Alonso  y  QUILCA-BARRERA, Lucero. Frequency of coinfection by respiratory pathogens and its impact on the prognosis of patients with COVID-19. Rev. Fac. Med. Hum. [online]. 2021, vol.21, n.3, pp.610-622. ISSN 1814-5469.


infection between other microorganisms and SARS-CoV-2, such as viruses, bacteria, and fungi, is an important factor in the management of COVID-19, which could increase the difficulties in diagnosis, management, prognosis, and even increase symptoms and mortality.


This review aims to describe the published scientific evidence regarding coinfection in patients with COVID-19.


A bibliographic search of studies published in Spanish or English was carried out using the PubMed, The Cochrane Library, and Google Scholar search engines; studies published between January 2020 and January 24, 2021 were searched.


Included 25 articles from various continents (America, Asia, and Europe). All the studies had patients with a confirmed diagnosis of COVID-19 added to some other test that identified some coinfection. Studies were identified 18 studies showing bacterial coinfection, 17 viral coinfection studies, and 5 fungal coinfection studies. The prevalence of coinfection showed significantly different figures according to the population studied and diagnostic criteria.


The presence of coinfection seems to be linked to a higher frequency of unfavorable outcomes. However, it is important to develop Latin American studies, given the heterogeneity in the studies seen in the different countries. Standardized definitions should be developed to be able to assess the impact of coinfections in patients diagnosed with COVID-19.

Palabras clave : Co-infection; COVID-19; review; prognosis (Source: MeSH NLM)..

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