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Revista de la Facultad de Medicina Humana

Print version ISSN 1814-5469On-line version ISSN 2308-0531


-VARGAS, Milagros Fuentes et al. Effect of orchidectomized and exogenous administration of testosterone on the quantification of platelets in male Wistar rats. Rev. Fac. Med. Hum. [online]. 2021, vol.21, n.4, pp.749-757. ISSN 1814-5469.


Anabolic-androgenic steroids (AAS) modify the physiological functioning of the cardiovascular system and have possible effects on the origin of cardiovascular thrombosis.


To determine the impact of the testosterone metabolite on platelet quantification in ORX rats with or without DHT replacement.

Material and methods:

24 male 45-day-old Wistar rats underwent orchidectomy with a simple scrotal incision. At 2.5 months of age, the 24 rats were divided into 4 study groups. Half of the 12 male ORX rats received hormone replacement with dihydrotestosterone propionate (DHT) at a 2 mg/kg dose via subcutaneous injection for 7 days and the other half received a physiological solution (0.9% NaCl). The same occurred in the 12 non-ORX males (SHAM). After 7 days of the administration, blood was collected by orbital puncture, and platelet quantification was performed.


A significant difference (ANOVA, p < 0.005) was found between the 4 groups. When performing the Dunn Method, a significant difference (p < 0.05) was found in the endogenous administration of DHT between Sham rats and rats ORX + 0.9% NaCl but not with ORX + DHT.


DHT induces an increase in platelet quantification inrats Sham and not in ORX rats with DHT, which may affect the increase in platelet quantification.

Keywords : Androgens; testosterone; anabolic; hemostasis, platelets, DHT. (Source: MeSH NLM)..

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