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Revista de la Facultad de Medicina Humana
versão impressa ISSN 1814-5469versão On-line ISSN 2308-0531
Resumo
HILARIO, César Braulio Cisneros et al. Safety and protective effects of Cenchrus Echinatus on induced breast cancer in Rattus Rattus. Rev. Fac. Med. Hum. [online]. 2022, vol.22, n.3, pp.452-462. Epub 09-Jul-2022. ISSN 1814-5469. http://dx.doi.org/10.25176/rfmh.v22i3.4915.
Introduction:
Breast cancer is a disease that is increasing its incidence yearly; it is thus in search of complementary alternatives for treatment, some medicinal plants containing large amounts of polyphenols have been studied, which have anti-cancer effects as is the case of Cenchrus echinatus L.
Objective:
determine the safety and protective effect of the extract ethanolic of Cenchrus echinatus L. (cadillo) on 7,12-Dimethylbenzo[a]anthracene DMBA-induced breast cancer in Rattus rattus.
Methods:
Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity (DL50) and toxicity at 45 days were calculated by methods of the probits and OECD respectively; to evaluate the protective effect the method of Barros 2004 was used, also the proliferation of tumor cells was recorded microscopically, using descriptive and inferential statistical analysis, considering p<0.05.
Results:
The safety studies demonstrate that the extract does not induce significant changes at the hematological, biochemical, and anatomopathological levels. A 76.92 % of the protective effect of the extract against DMBA-induced breast cancer in rats was achieved.
Conclusions:
It has been shown that the extract of Cenchrus echinatus L. presents a protective effect on 7,12-Dimethylbenzo[a]anthracene-induced breast cancer in Rattus rattus, and is not toxic to mice and rats.
Palavras-chave : echinatus L.; Breast cancer; DMBA. (fuente: MeSH NLM)..