Abstract

DIAZ-CUCHO, Omar. The difficult pathway of natriuretic peptides in heart failure. Rev. Fac. Med. Hum. [online]. 2023, vol.23, n.3, pp.140-147.  Epub Sep 21, 2023. ISSN 1814-5469.  http://dx.doi.org/10.25176/rfmh.v23i3.5089.

This review is conducted on the role of natriuretic peptides and the attempts to use them as a treatment as their role in the pathophysiology of heart failure with depressed systolic function was better understood. A recount of their participation in successive failed studies is provided, explaining the reasons for their failures, until achieving the desired success with the combination of sacubitril/valsartan. This produced a paradigm shift in the management of heart failure.

Keywords : Heart failure; natriuretic peptides; sacubitril-valsartan; neprilysin..

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