Abstract

HUAMAN SAAVEDRA, Juan et al. Hypolipidemic effect of aqueous extract of Gentianella thyrsoidea (Hook.) Fabris (Japallanshacoc) in Sprague Dawley rats. Rev. investig. Altoandin. [online]. 2019, vol.21, n.3, pp.165-172. ISSN 2313-2957.  http://dx.doi.org/10.18271/ria.2019.474.

Gentianella thyrsoidea (Hook.) Fabris is an herbaceous species that grows in localities of the north of Peru, at 3800-4900 m.a.s.l. Despite the wide popular use, no studies have been found to determine its lipid-lowering activity, so this research is aimed to evaluate the hypolipidemic effect of aqueous extract of Gentianella thyrsoidea in Sprague Dawley rats with induced hyperlipidemic. Twenty-four male specimens of Rattus norvegicus Sprague Dawley strain were randomly divided into two experimental groups (EG₁ and EG₂) and one control group (CG). Every group was induced to hyperlipidemia by administration of 2.5 ml/day of fused tallow trough orogastric way per two weeks. They were given treatment for three weeks: aqueous extract of Gentianella thyrsoidea to experimental groups (250 mg/kg and 500 mg/kg respectively) and saline solution to control group. Basal, post-induction and post-treatment plasma lipid profile was measured. Cholesterol, triglycerides and LDL levels showed significant differences between groups (p <0.05) after treatment. Cholesterol decreased 20.7% and 19.4% in EG₁ and EG₂ respectively, in CG increased 0.91%; triglycerides decreased 49.63% and 41.55% in EG₁ and EG₂ respectively, in CG decreased 18.76% but it was not significant; LDL decreased 34.64% and 28.24% in EG₁ and EG₂ respectively, in CG increased by 7.58%. The aqueous extract of Gentianella thyrosidea significantly decreased the levels of total cholesterol, triglycerides and LDL, evidencing to be a therapeutic alternative for the treatment of dyslipidemias

Keywords : Gentianella thyrsoidea; cholesterol; triglycerides; hyperlipidemia.

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