Abstract

LEIVA SALINAS, Milagros; MOYA VEGA, Víctor Raúl; MEJIA DELGADO, Elva Manuela  and  OBERTI, Juan Carlos. Anxiolytic effect in vivo of the ethanolic extract of Passiflora salpoense S. Leiva & Tantalean (Passifloraceae) in "albino mice" Balb/c. Arnaldoa [online]. 2019, vol.26, n.1, pp.391-408. ISSN 1815-8242.  http://dx.doi.org/10.22497/arnaldoa.261.26120.

This investigation had as objective to evaluate in vivo the anxiolytic effect of the ethanolic extract of Passiflora salpoense (Passifloraceae) in "albino mice" Balb/c. For this, we worked with 20 Balb/c mice that were randomly distributed in 4 groups for administering them orally in the following way: G1: control group 0.2 ml saline solution, G2: diazepam group 1 mg/kg, G3: group 50 mg/kg of ethanolic extract of P. salpoense, and G4: group 100 mg/kg of ethanolic extract of P. salpoense. Then, the mice were induced to anxiety using the marble burying test. The results showed that the G3 and G4 groups significantly decreased the number of buried spheres with a mean of 9.60 ± 1.82 and 4.20 ± 1.30 respectively, compared to the control group (G1) whose mean was 17.20 ± 3.03. Likewise, the G3 and G4 groups presented a response similar to the G2 group whose mean was 3 ± 0.71. For this reason, it was concluded that the doses of 50 mg/kg and 100 mg/kg of the ethanolic extract of Passiflora salpoense significantly reduce anxiety levels (p < 0.05).

Keywords : Passiflora salpoense; ethanolic extract; anxiety; marble burying test.

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