INTRODUCTION

Intermittent fasting or intermittent food restriction (RAI), as it is also known, is a lifestyle approach applied to individuals whose objective is mainly the regulation of body weight¹. The evidence shows that the practice of RAI has favorable repercussions on health; not only because of the progressive weight loss, but also because of the consequence it has on the muscular system². That is to say, it implies a benefit on the metabolism. Some authors affirm that this practice also has a positive effect on other health conditions, including the value of blood pressure, lipid profile and muscle mass index (BMI).

Harmful habits, unhealthy eating, sedentary lifestyle, insufficient sleep, among others, will lead to obesity, high blood pressure, dyslipidemia; all of them will lead to an increase in cardiovascular risk and, therefore, the propensity to suffer a cardiovascular event^3,4.

According to the WHO, in 2011, there were around 17 million individuals who died from some cardiovascular disease (29.82%) and it was estimated that for the present (2020) this number would increase by 15 to 20%. Also, it was predicted that by 2030 around 23.6 million individuals will die; this being the main cause of death worldwide⁵. In Peru, after a study conducted in which cardiovascular risks versus risk factors were addressed in a hospital in Lima, it was found that a large percentage of the individuals evaluated suffered from obesity and / or diabetes mellitus; both are metabolic disorders that lead to increased cardiovascular risk⁶

Due to the aforementioned, the objective of this study is to evaluate the effect of the 16/8 intermittent fasting scheme against anthropometric measurements, lipid profile values and cardiovascular risk.

METHODS

RESULTS

Prior to performing the 16/8 intermittent fasting scheme, the mean and standard deviation obtained from the fifteen participants were: for age it was 47.1 years ± 11.4; for height it was 1.66 meters ± 0.10; for initial body weight it was 84.3 ± 17.6 Kg; for BMI it was 30.4 ± 5.14 Kg / m2; ICC was 0.9 ± 0.05; for abdominal circumference it was 99.8 ± 10.6; for total cholesterol, HDL and LDL were 240.0 ± 42.8, 43.7 ± 10.6 and 153.2 ± 43.8 respectively. For cardiovascular risk according to Framingham it was 12.0% ± 0.09 and total cholesterol / HDL and LDL / HDL indices of 5.88 ± 2.16 and 3.6 ± 1.3 respectively. In addition, it was established whether or not the participant was a smoker; the type of diet recommended; as well as whether or not they had diabetes mellitusTable 1.

After the intervention, the results obtained were: for body weight, 84.3 ± 17.6 vs. 76.8 ± 15.9; for BMI, 30.4 ± 5.14 vs. 27.7 ± 4.8; the evaluation of the other parameters is presented inTable 2.

The results for lipid profile are shown inTable 3; as well as the results of the cardiovascular risk obtained according to the Framingham table and the risk indices for coronary heart disease.

Figure 1: The median (in orange), the maximum value (in blue) and the minimum value (in yellow) are placed. A. Weight before and after the intervention. B. body mass index before and after the intervention. C. Abdominal circumference before the intervention and after the intervention. D. Waist-to-hip ratio before the intervention and after the intervention 

Figure 2: The median (in orange), the maximum value (in blue) and the minimum value (in yellow) are placed. A. Systolic blood pressure before the intervention and after the intervention. B. Diastolic blood pressure before the intervention and after the intervention. C. Total cholesterol before the intervention and after the intervention. D. HDL cholesterol before the intervention and after the intervention. E. LDL cholesterol before the intervention and after the intervention 

Figure 3: The median (in orange), the maximum value (in blue) and the minimum value (in yellow) are placed. A. Cardiovascular risk according to Framingham before the intervention and after the intervention. B. I.R.E.C * (Total cholesterol / HDL index) before the intervention and after the intervention. C. I.R.E.C ** (LDL / HDL Index) before the intervention and after the intervention 

DISCUSSION

The presentation of these series of clinical cases indicated that the 16/8 intermittent fasting scheme has an impact on the factors evaluated such as weight, BMI, CHF, abdominal circumference, T-c, HDL-c, LDL-c, R.C. and I.R.E.C. in a variable way in each of the participants, the latter is related to the type of diet carried out. It is very important to highlight that, although in all reported cases a reduction in cardiac risk has been seen, in the case of one of the participants this decrease is much more noticeable (31% vs. 10%), this is probably due to the marked reduction in both your systolic and diastolic blood pressure; as well as, the decrease in total cholesterol.

Regarding the I.R.E.C., in most of the participants a reduction of the indices was found for both c-T / c-HDL; as well as for LDL-C / HDL-C; Likewise, authors such as Camelo et al.⁷, Peterson.⁸, Malinowski et al.⁹Haiyan¹⁰, demonstrated through their studies the reduction of the values within the lipid profile. The latter is also a risk factor for contracting cardiovascular disease. Therefore, the application of some intermittent fasting scheme would help to reduce the values within said profile; and, consequently, the reduction of the risk of some cardiovascular event.

In relation to body weight and BMI, the fifteen participants presented a reduction in these values, the most striking case being in one of them (92 Kg vs 78.9 Kg.) And (30.04 Kg / m2 vs 25.75 Kg / m2), which In addition to the 16/8 intermittent fasting scheme, he consumed a hypocaloric and hyperprotein diet.

When conducting an exhaustive review, it was found that authors such as Rosa Fernandez et al.¹¹, Harris et al.¹², Johnstone.¹³, Tinsley and La Bounty.¹⁴, Antoni et al.¹⁵, among others, demonstrate in their studies the impact from intermittent fasting versus the fight against overweight and obesity; which today have become a worldwide evil, being one of the main causes of contracting cardiovascular disease. His studies showed that intermittent fasting is a good method to reduce the weight of the individual; However, it must consider the effort that this practice entails; since it has been shown that during the first weeks the adaptation process will be complicated and is the main cause of abandonment of this approach to lifestyle.

Regarding the evaluation of CHF and the measurement of the abdominal circumference, all the participants showed reduction; However, the reduction in CHF was much more marked in one of them (1.5 vs. 0.97) and that of abdominal circumference, in another (115.6 vs. 97.8); the latter consumed a hypocaloric diet. This reduction could in turn be related to the decrease in coronary risk. Authors such as Mukai et al.¹⁶, Ahmet et al.¹⁷, Ramasamy et al.¹⁸highlighted the benefits obtained in their studies on the heart.

During the evaluation of systolic and diastolic blood pressure, a reduction was observed in most of the participants, which, at the time of their evaluation, could be classified as arterial hypertension; or maintenance of blood pressures when the participant was in the normal range. In two of the participants, a significant reduction in SBP was observed (150 mmHg vs. 110 mmHg) (170 mmHg vs. 130 mmHg), respectively. Tinsley and Horne.¹⁹, Mattson et al.²⁰evidenced the impact on blood pressure, demonstrating its reduction during their study.

When assessing the lipid profile, in the fifteen participants it was possible to see a reduction on the c-T values. Regarding LDL-C, 14 of the participants showed a reduction in values. Authors such as Meng et al¹⁰point out that intermittent fasting is effective for controlling the lipid profile; however, he emphasizes that in relation to HDL it does not show a significant effect, but suggests that a further study be carried out.

Some aspects that require special attention of this approach within lifestyle medicine could be the difficulties and peculiarities of its application; that is to say, its application may not be adjusted to the reality of all patients; therefore, there must be very clear selection criteria for patients who are candidates for this approach; for example, those who suffer from severe hypertension, kidney disease, high LDL levels, high uric acid levels, and type 1 diabetes mellitus may have contraindications; which does not occur in individuals with type 2 diabetes mellitus.²¹

It is important to emphasize, then, that the benefits of intermittent fasting on the cardiovascular system are varied and with its application many of the patients who are within the risk group, with the exception of those previously mentioned, would find a possibility of improvement in his life style.

The main limitations were the difficulty in data collection and mobilization to obtain them, because during the time interval taken to carry out the study, it combined with the world situation due to COVID-19. Furthermore, the adjustment for type of diet is not being considered and there is no group for comparison.

CONCLUSION

Although the application of intermittent fasting as a contingency plan against cardiovascular diseases requires many more studies. It is concluded that the intermittent fasting scheme showed a significant reduction in anthropometric measurements, lipid profile and blood pressure, and cardiovascular risk. Additionally, an increase in HDL-cholesterol was observed in the sample studied.